Senomyx

News Release

SENOMYX, SOLAE REACH MILESTONE IN EFFORT TO IMPROVE TASTE OF SOY PROTEIN

Innovative "Bitter Blocker" Technology Could Help Improve Diets

SAN DIEGO, CA and ST. LOUIS, MO, September 15, 2008 /PRNewswire-FirstCall/ -- Senomyx, Inc. (Nasdaq: SNMX), a leading company focused on using proprietary technologies to discover and develop novel flavor ingredients for the food, beverage, and ingredient supply industries, and Solae, the leading supplier of soy protein for food products, announced today they have reached critical milestones in their collaboration to develop bitter blockers that improve the taste of soy protein.

"We are excited about the progress we have made and look forward to the end results and how we can help our customers and consumers," said Jon McIntyre, Solae Vice President of Technology and Innovation. "After one year of research and collaboration, we are making excellent progress, and our teams are one step closer to identifying the systems that could help Solae enhance the flavor profile of soy protein."

Food manufacturers use a variety of techniques to mask undesirable bitter tastes, such as adding sugar, fat or salt to a recipe. The collaboration between Senomyx and Solae aims to develop new bitter blockers that better modulate and control bitterness in certain soy-based products. These innovations could improve the nutritional value of foods by allowing manufacturers to add more protein and use less sugar, salt and fat in their products. The bitter taste blockers may also accelerate consumer acceptance of nutritious foods containing soy protein.

"The rapid pace of our progress with the Solae bitter blocker program underscores the value of Senomyx's proprietary technologies," added Mark Zoller, Ph.D., Senomyx's Chief Scientific Officer and Executive Vice President of Discovery and Development. "In relatively short order, we worked with Solae's scientists and determined the components of soy protein responsible for its bitterness, identified the bitter taste receptors activated by these components, and discovered potential new ingredients that modulate the receptor response in our assay. We are very pleased with the accomplishments being made by the Senomyx Bitter Blocker team in collaboration with our Solae partners."

In April 2007, Senomyx and Solae entered into a collaborative agreement for the discovery, development and commercialization of novel flavor ingredients intended to enhance the taste characteristics of soy proteins.

Solae Vice President of New Business Development Miguel Angelo de Oliveira noted the Solae-Senomyx partnership will drive new innovation opportunities for Solae and its customers.

"The partnership with Senomyx will yield significant opportunities to enhance and advance soy protein's profile and role in food products," Oliveira said. "This partnership is one of the many new business and technology initiatives that Solae anticipates embarking on in the coming years. We are dedicated to advancing global nutrition through food ingredient innovation."

Soy protein is used in a wide variety of products, including energy bars, breakfast cereals, infant formula and beverages. As consumer demand for healthier food options increases, food manufacturers are increasingly looking to formulate products with soy protein. The companies expect to develop novel soy protein flavor enhancers and taste modulators using Senomyx's proprietary taste receptor-based assays and screening technologies.

"The advances being made in Senomyx's collaboration with Solae are an indication of the potential benefits that Senomyx can bring to our partner companies," stated Kent Snyder, President, Chief Executive Officer, and Chairman of the Board of Senomyx. "Our programs are intended to develop flavor ingredients that reduce bitterness, sugar, and salt without compromising taste, allowing our partners to provide new choices for consumers seeking tasteful products with improved nutritional profiles."

Under the licensing agreement, Solae will have exclusive worldwide use of the flavor ingredients in virtually all categories of foods and beverages that contain added soy protein. Solae will fund the discovery and development of these flavor systems, and Senomyx will be entitled to certain milestone and royalty payments based on sales of Solae products containing any flavor ingredients developed under the agreement.

About Senomyx, Inc.

Senomyx is a leading company using proprietary taste receptor technologies to discover and develop novel flavor ingredients in the savory, sweet, salt, bitter, and cooling areas. Senomyx has entered into product discovery and development collaborations with seven of the world's foremost food, beverage, and ingredient supply companies: Ajinomoto Co., Inc., Cadbury plc, Campbell Soup Company, The Coca-Cola Company, Firmenich SA, Nestle SA, and Solae. Nestle is currently marketing products that contain one of Senomyx's flavor ingredients. For more information, please visit http://www.senomyx.com.

About Solae

Solae, LLC is the global leader in the research, development and manufacture of soy protein ingredients. Headquartered in St. Louis, Missouri, USA, with annual revenue exceeding $1 billion, the company is a joint venture between DuPont and Bunge Limited. For more information, visit http://www.solae.com.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding: the capabilities of Senomyx's flavor ingredients; Senomyx's ability to discover new flavor ingredients; and Senomyx's ability, or Senomyx's collaborators' ability, to commercialize products incorporating Senomyx's flavor ingredients in packaged foods and beverages. Risks that contribute to the uncertain nature of the forward-looking statements include: Senomyx is dependent on its product discovery and development collaborators for all of Senomyx's revenue; Senomyx is dependent on its current and any future product discovery and development collaborators to develop and commercialize any flavor ingredients Senomyx may discover; Senomyx may be unable to develop flavor ingredients useful for formulation into products; Senomyx or its collaborators may be unable to obtain and maintain the regulatory approval required for flavor ingredients to be incorporated into products that are sold; even if Senomyx or its collaborators receive a regulatory approval and incorporate Senomyx flavor ingredients into products, those products may never be commercially successful; and Senomyx's ability to compete in the flavor ingredients market may decline if Senomyx does not adequately protect its proprietary technologies. These and other risks and uncertainties are described more fully in Senomyx's most recently filed SEC documents, including its Annual Report on Form 10-K and Quarterly Report on Form 10-Q, under the headings "Risks Related to Our Business" and "Risks Related to Our Industry." All forward-looking statements contained in this press release speak only as of the date on which they were made. Senomyx undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

Contacts:
Gwen Rosenberg
Senomyx, Inc.
Vice President, Investor Relations & Corporate Communications
858-646-8369
gwen.rosenberg@senomyx.com

Natasha Webster
Solae
Senior Manager, Global Communications
314-659-3626
nwebster@solae.com

SOURCE Senomyx, Inc.